منابع مشابه
ALOX 15 ( arachidonate 15 - lipoxygenase )
Hugo: ALOX15 Other names: 15-LOX; EC 1.13.11.33; arachidonate omega 6-lipoxygenase; LOG15 Location: 17p13.3 Local order: Genes flanking ALOX15 in centromere to telomere direction on 17p13 are: MYBBP1A 17p13.3 MYB binding protein (P160) 1a, GGT6 17p13.2 homolog of gammaglutamyltransferase 6, LOC124974 17p13.2, thioredoxin 1 pseudogene 4, SMTNL2 17p13.2 smoothelin-like 2, ALOX15 17p13.2 arachidon...
متن کاملExpression of 15-Lipoxygenase-1 in Human Colorectal Cancer
Recently, we reported the induction of reticulocyte type 15-lipoxygenase (15-Lox-1) in a human colorectal carcinoma cell line that had been stimulated by butyrate to undergo apoptosis and cell differentiation (H. Kamitani et al., J. Biol. Chem., 273: 21569–21577, 1998). To determine if 15-Lox-1 is expressed in human colorectal cancer tissue, 21 matched pairs of colorectal tumor and adjacent nor...
متن کاملCell damage unmasks 15-lipoxygenase activity in human neutrophils.
Metabolism of arachidonic acid (10 microM) into 15(S)-hydroxyl-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE) was proportional to lactate dehydrogenase release from human neutrophils incubated with supratherapeutic concentrations of non-steroidal anti-inflammatory agents. In contrast to others (Vanderhoek, J., and Bailey, J. (1984) J. Biol. Chem. 259, 6752-6756), we report that increased 1...
متن کاملEffects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene.
Human 15-lipoxygenase (h15-LO) is present on chromosome 17p13.3 in close proximity to the tumor-suppressor gene, p53. 15-LO is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. The murine BALB/c embryo fibroblast cell line, (10)1val, expresses p53 in mutant (mt) conformation when grown at 39 degrees C and in wild-type conformation when grown at 32 degrees C...
متن کاملOleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Inhibition of lipoxygenase (LO) is currently an important goal of biomedical research due to its critical role in asthma, atherosclerosis, and cancer regulation. Steady-state kinetic data indicate that oleic acid (OA) is a simple competitive inhibitor for soybean lipoxygenase; however, kinetic isotope effect (KIE) data suggest a more complicated inhibitory mechanism. To investigate the inhibito...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)39346-8